Clinical study of 9 patients with acquired thrombotic thrombocytopenic purpura

  • Hong Qu Pan Yu Central Hospital, GuangDong, China
Keywords: keywords: Purpura, thrombotic thrombocytopenia; von Willebrand factor lyase; clinical features; treatment

Abstract

bjective: To analyze the clinical features, treatment strategies and outcomes of patients with acquired thrombocytopenic purpura (TTP). Methods: The clinical data of 9 patients with acquired TTP were retrospectively analyzed. Using SPSS 13.0 software for data analysis. Results: There were 4 males and 5 females in 9 patients, with a median age of 43 (24-72) years. Five patients (55.56%) showed typical pentadia syndrome. Thrombocytopenia (100%), microangiopathy Anemia (100%), fever (88.89%) is more common, while the nervous system symptoms (77.78%) and kidney damage (55.56%) is relatively rare. Two patients were tested for plasma von Willebrand factor (ADAMTS13) activity, with activities of 2.4% and 4.4%, respectively. Four patients (44.44%) were treated effectively, and the effective rate of plasma exchange and plasma infusion was 55.56%. Five patients died without recurrence. The average age of onset of death was higher than that of the effective patients (52.2 ± 16.52 VS 32.25 ± 11.44), but the difference was not statistically significant (P = 0.081). Conclusion: Concurrent clinical fever, hemolysis and bleeding tendency need to consider the possibility of TTP. Detection of plasma ADAMTS13 activity contributes to the clinical diagnosis of TTP. Early diagnosis and timely application of plasma therapy can help control the disease. The prognosis of elderly patients is relatively poor.

Published
2017-12-18
How to Cite
Qu, H. (2017, December 18). Clinical study of 9 patients with acquired thrombotic thrombocytopenic purpura. Journal of Clinical and Experimental Medicine, 1(3), 1. https://doi.org/https://doi.org/10.29422/jocem.2017.03.001
Section
Clinical and Experimental Medicine